New Jersey Center for Biomaterials

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2008

Papers

T. Briggs, M.D. Treiser, P.F. Holmes, J. Kohn, P.V. Moghe, T.L. Arinzeh, "Osteogenic differentiation of human mesenchymal stem cells on poly (ethylene glycol)-variant biomaterials." J Biomed Mater Res A. 2008 Dec 18. PMID: 19097152.

P.E. Holmes et al, "Exploration of polymethacrylate structure–property correlations: Advances towards combinatorial and high-throughput methods for biomaterials," Progress in Polymer Science 2008 33: 787–796.

V. Kholodovych, A.V. Gubskaya, M. Bohrer, N. Harris, D. Knight, J. Kohn, W.J. Welsh, "Prediction of biological response for large combinatorial libraries of biodegradable polymers: polymethacrylates as a test case." Polymer, 2008 49 (10): 2435-2439.

R.A. Latour, "Molecular dynamics simulation of protein-surface interactions: Benefits, problems, solutions, and future directions." Biointerphases, 2008 3: FC2 – FC12.

C.P. O’Brien, S.J. Stuart, D.A. Bruce, R.A. Latour, "Modeling of peptide adsorption interactions with a poly (lactic acid) surface." Langmuir, 2008 24: 14115-14124 PMID: 19007142.

R. Rojas, J. Kohn, "Rational design and exploration of polymer space through combinatorial and high-throughput approaches with the application in mind," In ACS POLYMER Preprints, American Chemical Society: Philadelphia, PA, 2008.

R. Rojas, N. Harris, J. Kohn, "Evaluation of automated synthesis for chain and step-growth polymerizations: Can robots replace the chemists?" In ACS PMSE Preprints, American Chemical Society: New Orleans, LA, 2008.

H. J. Sung, K. M. Sakala Labazzo, D. Bolikal, M.J. Weiner, R. Zimnisky, J. Kohn, "Angiogenic competency of biodegradable hydrogels fabricated from polyethylene glycol-crosslinked tyrosine-derived polycarbonates." Eur Cell Mater. 2008 Apr 25; 15:77-87 PMID: 18438755.

Y. Yang, D. Bolikal, M.L. Becker, J. Kohn, D. Zieger, C.G. Simon, "Combinatorial Polymer Scaffold Libraries for Screening Cell-Biomaterial Interactions in 3D." Advanced Materials, 2008, 20(11) 2037-2043.

Y. Yang, S.D. Dorsey, M.L. Becker, S. Lin-Gibson, G.E. Schumacher, G.M. Flaim, Kohn, J, C.G. Simon, "X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods." Biomaterials, 2008, 29(12), 1901-1911.

2007

Papers

K. Bhadriraju, M. T. Yang, S. A. Ruiz, D.M. Pirone, J.L. Tan, C.S. Chen. Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Experimental Cell Research. 313: 3616-3623(2007).

A. V. Gubskaya, V. Kholodovych, D. Knight, J. Kohn, W. J. Welsh. Prediction of fibrinogen adsorption for biodegradable polymers: Integration of molecular dynamics and surrogate modeling Polymer 48: 5788-5801(2007).

N. K. Harris, J. Kohn, W. J. Welsh, D. Knight. Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA. Editor(s): Narasimhan, Balaji; Mallapragada, Surya K.; Porter, Marc D. Combinatorial Materials Science (2007), 163-200.

J. Kohn, W. Welsh and D. Knight, "A New Approach to the Rational Discovery of Polymeric Biomaterials", Biomaterials, Vol. 28, No. 29, 2007, pp. 4171-4177.

X.F. Li, C.P. O'Brien, G. Collier, N.A. Vellore, F. Wang, D.A. Bruce, S.J. Stuart, R.A. Latour, “An Improved Replica-Exchange Sampling Method: Temperature Intervals with Global Energy Reassignment (TIGER),” J. Chem. Phys. (2007), 127, article 164116, pg.1-10.
** Selected to also be highlighted in the Virtual Journal of Biological Physics Research, Vol. 14, Issue 9, Statistical and Nonlinear Physics Section, Nov. 1, 2007.

E. Liu, M. D. Treiser, P. A. Johnson, P. Patel, A. Rege, J. Kohn, P. V. Moghe, "Quantitative biorelevant profiling of material microstructure within 3D porous scaffolds via multiphoton fluorescence microscopy." (Journal of Biomedical Materials Research B, Applied Biomaterials.) 82B(2): 275-283.

S. A. Ruiz, C. S. Chen. Microcontact printing: a tool to pattern. Soft Matter 3(2):168-177 (2007).

J. Schut, D. Bolikal, I. Khan, A. Pesnell, A. Rege, R. Rojas, L. Sheihet, N.S. Murthy and J Kohn. Glass transition temperature prediction of polymers through the mass-per-flexible-bond principle Polymer 48:6115-6124 (2007).

C.G. Simon, J.S. Stephens, S.M. Dorsey, M.L. Becker. Fabrication of Combinatorial Polymer Scaffold Libraries” Review Scientific Instruments, 2007, 78, 072207

N. J. Sniadecki, A. Anguelouch, M.T. Yang, C.M. Lamb, Z. Liu, S. B. Kirschner, Y. Liu, D. H. Reich, C. S. Chen. Magnetic microposts as an approach to apply forces to living cells. Proc Nat Acad Sci . 104: 14553-14558(2007).

Y. Sun, B. N. Dominy, R. A. Latour, "Comparison of solvation-effect methods for the simulation of peptide interactions with a hydrophobic surface." (J. Comput. Chem). 28: 1883-1892.

M. D. Treiser, E. Liu, R. Dubin, H. Sung, J. Kohn, P. Moghe, "Profiling cell-biomaterial interactions via cell-based fluororeporter imaging." (BioTechniques). In press.

M.T. Yang, N.J. Sniadecki, C.S. Chen. Geometric considerations of micro- to nanoscale elastomeric post arrays to study cellular traction forces. Advanced Materials. 19: 3119–3123 (2007).

Y. Yang, S.D. Dorsey, M.L. Becker, S. Lin-Gibson, G.E. Schumacher, G.M. Flaim, J. Kohn, C.G. Simon. X-ray imaging optimization of 3D tissue engineering scaffolds via combinatorial fabrication methods. Biomaterials, 2008, doi:10.1016/j.biomaterials.2007.12.042

2006

Papers

Y. H. Bae, P. A. Johnson, C. A. Florek, J. Kohn, P. Moghe, "Minute Changes in Composition of Polymer Substrates Produce Amplified Differences in Cell Adhesion and Motility via Optimal Ligand Conditioning." Acta Biomaterial. (2006) June 20.

L. O. Bailey, M. L. Becker, J. Stephens, C. M. Mahoney, N. Washburn, A. Rege, J. Kohn, E. Amis, "Cellular Responses to Phase-separated Blends of Tyrosine-derived Polycarbonates." J. Biomed Mater. Res. (2006) 76(3); 491-502.

A. Sousa, A. Aitouchen, M. Libera, "Water Mapping in Hydrated Soft Materials," Ultramicroscopy (2006) 106(2): 130-45.

A. Sousa, M. Sengonul, R. Latour, J. Kohn. "Selective Protein Absorptin on a Phase-Separated Solvent-Cast Polymer Blend." Langmuir (2006) 22(14):6286-92.

Book Chapters

N. K. Harris, D. Knight, J. Kohn, W. J. Welsh. "Biomaterials Informatics" In Combinatorial Materials Science, Balaji Narasimham and Surya K. Mallpragada, eds., Wiley & Sons, 2006.

2005

Papers

S. D. Abramson, G. Alexe, P. L. Hammer, J. Kohn, "A Computational Approach to Predicting Cell Growth on Polymeric Biomaterials". J. Biomed. Mat. Res. (2005). 73(1): 116-24.

M. Agashe, V. Raut, S. J. Stuart, R.A. Latour, "Molecular Simulation to Characterize the Adsorption Behavior of a Fibrinogen Gamma-Chain Fragment", Langmuir (2005) 21: p. 1103–1117.

P. Krsko, I. Saaem, R. Clancy, H. Geller, P. Soteropoulos, M. Libera. "Electron-Beam Patterned Hydrogels to Control Nanoscale Surface Bioactivity," Nanofabrication: Technologies, Devices and Applicatiosn, Proc. SPIE Vol. 6002, W. Lai, L. Ocola, S. Pau, eds. (2005).

Y. Mei, T. Wu, C. Xu, K. Langenbach, J. T. Elliott, B. D. Vogt, K. L. Beers, E. J. Amis, N. R. Washburn, "Tuning Cell Adhesion on Gradient Poly(2-hydroxyethyl methacrylate)-grafted surfaces." Langmuir (2005). 21(26): 12309-14.

V. Raut, M. Agashe, S.J. Stuart, R. A. Latour, "Molecular Dynamics Simulations of Peptide-Surface Interactions", Langmuir, 2005. 21: 1629-1639.

E. J. Semler, A. Dasgupta, and P.V. Moghe, "Cytomimetic Engineering of Hepatocyte Morphogenesis and Function by Substrate-Based Presentation of Acellular E-Cadherin", Tissue Engineering (2005). 11(5-6): 734-50.

E. J. Semler, P. Lancin, A. Dasgupta, P. V. Moghe, "Engineering Hepatocellular Morphogenesis and Function via Ligand-Presenting Hydrogels with Graded Mechanical Compliance." Biotechnology and Bioengineering. (2005). 89(3): 296-307.

J. Smith, V. Kholodovych, D. Knight, J. Kohn, W. Welsh. "Predicting Fibrinogen Absorption to Polymeric Surfaces in Silico: A Combined Method Approach," Polymer (2005) 46(12), 4296-4306.

J. Smith, V. Kholodovych, D. Knight, W. Welsh, J. Kohn. "QSAR Models for the Analysis of Bioresponse Data from Combinatorial Libraries of Biomaterials," QSAR and Combinatorial Science (2005) 24, 99-113.

Y. Sun, W. Welsh, R. Latour. "Prediction of the Orientations of Absorbed Protein Using an Empirical Energy Function with Implicit Solvation." Langmuir (2005) 21: 5616-5626.

N. Weber, H. P. Wendel, J. Kohn, "Formation of Viscoelastic Protein Layers on Polymeric Surfaces Relevant to Platelet Adhesion," J. Biomed. Mater. Res. (2005) 72(4): 420-7.

Book Chapters

E. J. Semler and P. V. Moghe, Tissue Assembly Guided via Substrate Biophysics: Applications to Cellular Engineering. "Special Volume on Tissue Engineering, Advances in Biochemical Engineering/Biotechnology", Springer Verlag (Editors: David Kaplan and Kyongbum Lee) (2005).

2004

Papers

L. O. Baily, N. Washburn, C. G. Simon, E. S. Chan, F. W. Wang, "Quantification of Inflammatory Cellular Responses using Rea-Time Polymerase Chain Reaction" J. Biomed Mater. Res. (2004) 69A(2), 305-313.

Y. Hong, P. Krsko, and M. Libera, "Protein Surface Patterning Using Nanoscale PEG Hydrogels," Langmuir (2004), 20(25), 11123-11126.

S. B. Kennedy, N. R. Washburn, K. M. Yamada, E. J. Amis, C. G. Simon Jr., "High-throughput Investigation of Osteoblast Response to Polymer Crystallinity: Influence of Nanometer Scale Roughness on Proliferation" Biomaterials (2004) 25(7-8), 1215-1224.

J. Kohn, “New Approaches to Biomaterials Design”, Nature Materials, 2004. 3: p. 745-747.

V. Kholodovych, J. R. Smith, D. Knight, S. Abramson, J. Kohn, W. J. Welsh, “Accurate Predictions of Cellular Response using QSPR: A Feasibility Test of Rational Design of Polymeric Biomaterials”, Polymer, 2004. 45: p. 7367-7379.

Y. Mei, A. Kumar, W. Gao, R. Gross, S. B. Kennedy, N. R. Washburn, E. J. Amis, J. T. Elliott, "Biocompatibility of Sorbitol-Containing Polyesters. I. Synthesis, Surface Analysis and Cell Response in Vitro" Biomaterials (2004) 25(18), 4195-4201

R. I. Sharma, J. Kohn, and P. V. Moghe, "Poly(ethylene glycol) Enhances Cell Motility on Protein-based PEG-polycarbonate Substrates: A Mechanism for Cell-Guided Ligand Remodeling." J. Biomed. Mater. Res. (2004) 69A: p. 114-23.

J. R. Smith, D. Knight, J. Kohn, K. Rasheed, N. Weber, “Integration of Combinatorial Synthesis, Rapid Screening, and Computational Modeling in Biomaterials Development”, Macromol. Rapid Commun., 2004. 25: p. 127–140.

J. R. Smith, D. Knight, J. Kohn, K. Rasheed, N. Weber, V. Kholodovych, W. Welsh. “Using Surrogate Modeling in the Prediction of Fibrinogen Adsorption Onto Polymer Surfaces”, J. Chem. Inf. Comput. Sci., 2004. 44: p. 1088-1097.

N. Weber, D. Bolikal, S. Bourke and J. Kohn, “Small Changes in the Polymer Structure Influence the Adsorption Behavior of Fibrinogen on Polymer Surfaces: Validation of a New Rapid Screening Technique”, J. Biomed. Mater. Res., 2004. 68(A): p. 496-503.

Book Chapters

M. Libera and M.M. Disko, “Electron Energy Loss Spectroscopy of Polymers”, Transmission Electron Energy Loss Spectrometry in Materials Science, ed. C. Ahn, 419-454, Wiley-VCH Publishers (2004).

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