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Modeling Bioresponse to Polymers Semi-empirical Modeling Using the Biomaterials Store™
A full-day training course including theory, demonstration, and hands-on sessions
November 9, 2012 Day 3 of the 2012 RESBIO Short Course "Cells on Polymeric Biomaterials" A project of RESBIO – Biomedical Technology Resource on Polymeric Biomaterials What is Biomaterials StoreTM? .jpg) It is an open source database and a data-mining tool. It enables scientists and engineers to develop molecular models of polymeric biomaterials, allows the user to store structure- property data in a database, call data from the database to perform modeling tasks, and deploy different machine learning algorithms to predict bioresponse properties to polymeric biomaterials.Why RESBIO developed Biomaterials StoreTM? Developing new biomaterials is costly and time consuming. Biomaterials Store TM has the capability to accelerate the selection process of lead biomaterials. The tool can recommend, from a small set of experimental polymers, desirable polymers that have not even been synthesized or contemplated. How does Biomaterials StoreTM work? The central focus of the Store is to develop descriptors for a limited number of polymers for which experimental data about a response are available. These responses could be mechanical (Tg, modulus, etc.), biological (protein adsorption such as fibrinogen, peptides, cell attachment, cell growth, etc), or chemical. The modeling algorithms in the Store will develop a model correlating the responses to a set of polymer descriptors. This model then can be used to predict the response of a known polymer or conversely could suggest a polymer that would elicit a desirable response. Who should attend? • Scientists and engineers, industrial or academic, who are interested in screening large numbers of polymeric materials for therapeutic and product applications. • Those who are interested in predicting bioresponse to polymers in support of regulatory submissions. Where would the data come from? The data could be from your own laboratories, which you may choose or not to share. You will have access to data that have been approved for public use, which already exist in Biomaterials StoreTM. For more information, please contact Murty Vyakarnam, PhD Chief Operating Officer, RESBIO NJ Center for Biomaterials, Rutgers University 145 Bevier Road, Piscataway, NJ 08854 Ph: 732-445-0488 ext 40021 Fax: 732-445-5006 Email: vyakarnamm@dls.rutgers.edu |
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