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Ponstel (Mefenamic Acid)

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What is Ponstel

Ponstel, containing Mefenamic Acid as an active ingredient, belongs to the class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). It is specifically used for treating mild to moderate pain from various conditions, as well as pain related to menstrual cramps. Mefenamic Acid works by blocking the body's production of certain natural substances that cause inflammation, thereby reducing pain and swelling.


Ponstel is recommended for a short-term treatment of mild to moderate pain, including menstrual pain, for periods not exceeding 7 days. It is typically taken with food or milk to minimize stomach upset, usually four times a day when used for managing menstrual pain or as directed by a healthcare provider for other types of pain. Adherence to the prescribed dosage and duration is crucial to ensure effectiveness and minimize risks.

Precautions and Contraindications

Before using Ponstel, certain precautions and contraindications should be considered. It is contraindicated in individuals with known hypersensitivity to mefenamic acid or other NSAIDs. Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs should avoid Ponstel. Additionally, it should not be used by patients with active or past history of gastrointestinal bleeding, ulceration, inflammatory bowel disease, significant renal impairment, or in the setting of coronary artery bypass graft (CABG) surgery. Caution is advised for individuals with pre-existing liver disease, hypertension, or heart failure.


Ponstel may interact with several medications, potentially affecting its efficacy or increasing the risk of side effects. These include anticoagulants (such as warfarin), aspirin, other NSAIDs, corticosteroids, selective serotonin reuptake inhibitors (SSRIs), and medications affecting renal function. Alcohol and tobacco use may also exacerbate gastrointestinal risks. Patients should inform their healthcare provider about all the medications, supplements, and herbal products they are taking to avoid harmful interactions.

Side Effects

While Ponstel is effective for many, it may cause side effects in some users. Common side effects include upset stomach, nausea, dizziness, and headache. More severe side effects necessitating immediate medical attention include heart attack or stroke symptoms, gastrointestinal bleeding, hepatotoxicity, and severe allergic reactions. Like other NSAIDs, Ponstel may increase the risk of serious cardiovascular thrombotic events and gastrointestinal adverse reactions.

Before You Start Ponstel Treatment

A thorough evaluation by a healthcare professional is essential before initiating treatment with Ponstel. This evaluation should include a comprehensive medical history and assessment of current health conditions to determine if Ponstel is an appropriate and safe option. Monitoring for signs of gastrointestinal bleeding or cardiac events is recommended during treatment.


An overdose of Ponstel can be dangerous and requires immediate medical intervention. Symptoms of an overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma. In the event of a suspected overdose, it is vital to seek emergency medical help right away. Treatment for an overdose typically involves supportive care to stabilize the patient and manage any adverse symptoms.

Ponstel represents a valuable option for the management of pain, particularly menstrual pain, offering significant relief when used appropriately. However, careful consideration of the associated risks, side effects, and potential interactions with other substances is necessary. Through adherence to medical guidance and ongoing monitoring, patients can achieve effective pain management with Ponstel, enhancing their quality of life while minimizing the risks associated with its use.